Inhibition of Cav2.2-mediated signaling induces sensorimotor gating deficits
نویسندگان
چکیده
منابع مشابه
Sensorimotor gating deficits and hypofrontality in schizophrenia.
Patients with schizophrenia exhibit (a) deficient sensorimotor gating as indexed by impaired prepulse inhibition (PPI) of the startle eyeblink reflex suggesting abnormal automatic information processing and (b) abnormal attentional modulation of PPI suggesting impaired controlled information processing. Here we test the hypothesis of deficient attentional modulation of PPI in schizophrenia as a...
متن کاملSensorimotor Gating: Startle Submits to Presynaptic Inhibition
Prepulse inhibition is a type of sensorimotor gating that is disrupted in some neuropsychiatric disorders. Its cellular basis has eluded investigators but now, using a molluscan model system, a cellular mechanism has been established.
متن کاملSensorimotor gating and anxiety: prepulse inhibition following acute exercise.
This investigation examined whether gating related deficits among individuals with high trait anxiety could be moderated by an acute bout of exercise. Low (LA) and high (HA) trait anxious participants engaged in either a quiet rest or an exercise session on separate occasions. Replicating previous findings, HA participants exhibited significantly reduced PPI at lead intervals of 30 and 60 ms re...
متن کاملSensorimotor gating in larval zebrafish.
Control of behavior in the natural environment where sensory stimuli are abundant requires superfluous information to be ignored. In part, this is achieved through selective transmission, or gating of signals to motor systems. A quantitative and clinically important measure of sensorimotor gating is prepulse inhibition (PPI) of the startle response, impairments in which have been demonstrated i...
متن کاملClonidine normalizes sensorimotor gating deficits in patients with schizophrenia on stable medication.
BACKGROUND Cognitive deficits form core features in schizophrenia. Several studies have shown improvements in prefrontal cognitive function by α 2 -agonists in schizophrenia. In the present study, it was investigated whether clonidine (an α 2 -adrenoceptor agonist) could normalize sensorimotor gating deficits in schizophrenia. METHODS In a double blind, placebo controlled, randomized, yet bal...
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ژورنال
عنوان ژورنال: Integrative Molecular Medicine
سال: 2015
ISSN: 2056-6360
DOI: 10.15761/imm.1000151